Clozapine is an atypical antipsychotic that is used to treat treatment-resistant schizophrenia, and treatment-resistant bipolar disorder and used for reduction of recurrent suicidal behavior. According to Stahl (2021), “Clozapine is widely recognized as being particularly effective when other drugs for psychosis fail and is thus the “gold standard” for efficacy in schizophrenia. Clozapine is also the only antipsychotic that has been documented to reduce the risk of suicide in schizophrenia and may have a particular niche in treating aggression and violence in psychotic patients” (p. 222).
Clozapine works by blocking dopamine 2 receptors. This leads to the reduction of positive symptoms of psychosis and the stabilization of disturbing symptoms. It also blocks serotonin 2A receptors. This causes increased release of dopamine in the brain which decreases motor side effects and improves cognitive symptoms (Stahl, 2017).
One possible side effect of Clozapine is neutropenia. Neutropenia is a very low count of the white blood cell neutrophils. White blood cells help your body fight of infections. Having a very low WBC count can put the body at an increased risk for infection. It is important for the patient to have serial WBC checks while on Clozapine. Other side effects may include sedation, weight gain, orthostasis, tachycardia and tardive dyskinesia. Tardive dyskinesia (TD) symptoms include abnormal and involuntary movements of the face (specifically the tongue, jaw and lips). TD may sometimes become permanent. It is extremely important to recognize the symptoms of TD early so that an intervention can occur. An intervention may include lowering the dose of Clozapine or changing to a different drug entirely.
The time it takes for Clozapine to work is around 3 weeks. Dosing of Clozapine starts out with 25 mg at night. Then increase by 25-50 mg/day every 48-72 hours. The threshold for response is a plasma level of 350 ng/ml (Stahl, 2017).
Why Choose Us
Top Quality and Well-Researched Papers
We always make sure that writers follow all your instructions precisely. You can choose your academic level: high school, college/university or professional, and we will assign a writer who has a respective degree.
Professional and Experienced Academic Writers
We have a team of professional writers with experience in academic and business writing. Many are native speakers and able to perform any task for which you need help.
Free Unlimited Revisions
If you think we missed something, send your order for a free revision. You have 10 days to submit the order for review after you have received the final document. You can do this yourself after logging into your personal account or by contacting our support.
Prompt Delivery and 100% Money-Back-Guarantee
All papers are always delivered on time. In case we need more time to master your paper, we may contact you regarding the deadline extension. In case you cannot provide us with more time, a 100% refund is guaranteed.
Original & Confidential
We use several writing tools checks to ensure that all documents you receive are free from plagiarism. Our editors carefully review all quotations in the text. We also promise maximum confidentiality in all of our services.
Customer Support 24/7
Our support agents are available 24 hours a day 7 days a week and committed to providing you with the best customer experience. Get in touch whenever you need any assistance.
No need to work on your paper at night. Sleep tight, we will cover your back. We offer all kinds of writing services.
No matter what kind of academic paper you need and how urgent you need it, you are welcome to choose your academic level and the type of your paper at an affordable price. We take care of all your paper needs and give a 24/7 customer care support system.
Admission and Business Papers
An admission essay is an essay or other written statement by a candidate, often a potential student enrolling in a college, university, or graduate school. You can be rest assurred that through our service we will write the best admission essay for you.
Editing and Proofreading
Our academic writers and editors make the necessary changes to your paper so that it is polished. We also format your document by correctly quoting the sources and creating reference lists in the formats APA, Harvard, MLA, Chicago / Turabian.
If you think your paper could be improved, you can request a review. In this case, your paper will be checked by the writer or assigned to an editor. You can use this option as many times as you see fit. This is free because we want you to be completely satisfied with the service offered.